Filtered By:
Cancer: Non-Small Cell Lung Cancer

This page shows you your search results in order of date.

Order by Relevance | Date

Total 68605 results found since Jan 2013.

Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Lung Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research

Oncologic outcomes of segmentectomy versus lobectomy for clinical T1c radiological pure-solid non-small cell lung cancer
CONCLUSIONS: In T1c radiological pure-solid non-small cell lung cancer, segmentectomy was significantly associated with worse survival and insufficient loco-regional cancer control. Lobectomy remains the standard surgical treatment; meanwhile, segmentectomy should be applied with great caution.PMID:37738593 | DOI:10.1093/icvts/ivad152
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Aritoshi Hattori Kazuya Takamochi Takeshi Matsunaga Mariko Fukui Kenji Suzuki Source Type: research

Activation of PI3K/Akt pathway by G protein ‐coupled receptor 37 promotes resistance to cisplatin‐induced apoptosis in non‐small cell lung cancer
ConclusionsIt was suggested that GPR37 acts a crucial role in promoting the occurrence and development of NSCLC. Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC. Therefore, our findings demonstrated that GPR37 may represent a viable therapeutic target for NSCLC.
Source: Cancer Medicine - September 22, 2023 Category: Cancer & Oncology Authors: Han Liu, Yingjie Zhu, Huikun Niu, Jing Jie, Shucheng Hua, Xiaoxue Bai, Shuai Wang, Lei Song Tags: RESEARCH ARTICLE Source Type: research

Cancers, Vol. 15, Pages 4684: Prognostic Factors in Advanced Non-Small Cell Lung Cancer Patients Treated with Immunotherapy
re Gridelli Taking into account the huge epidemiologic impact of lung cancer (in 2020, lung cancer accounted for 2,206,771 of the cases and for 1,796,144 of the cancer-related deaths, representing the second most common cancer in female patients, the most common cancer in male patients, and the second most common cancer in male and female patients) and the current lack of recommendations in terms of prognostic factors for patients selection and management, this article aims to provide an overview of the current landscape in terms of currently available immunotherapy treatments and the most promising assessed prognostic...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Danilo Rocco Luigi Della Gravara Angela Ragone Luigi Sapio Silvio Naviglio Cesare Gridelli Tags: Review Source Type: research

Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib
Several cases of STRN-ALK fusion have been reported, and some anaplastic lymphoma kinase (ALK) inhibitors have been shown to be effective for treatment. Nevertheless, no cases of COVID-19 leading to heart failure and respiratory failure have been reported in people older than 70 years treated with ALK inhibitors. The present case report describes a 70-year-old patient with usual chronic obstructive pulmonary disease, diabetes, depression, and carotid plaque disease. Next-generation sequencing of tissue obtained by puncture biopsy revealed a STRN-ALK mutation accompanied by a TP53 mutation. The patient was treated with ensa...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Choice of radiotherapy modality for the combined treatment of non-small cell lung cancer with brain metastases: whole-brain radiation therapy with simultaneous integrated boost or stereotactic radiosurgery
ConclusionIn the context of systemic drug therapy, WBRT+SIB may have better intracranial local control than SRS in NSCLC-BM patients.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Hsa_circ_0102899 promotes epithelial –mesenchymal transition in non-small cell lung cancer
Conclusioncirc_0102899 promotes EMT and metastasis in NSCLC by regulating the miR-885-5p/EIF4G2 axis.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer
ConclusionsAnagliptin can enhance PD-L1 blockade efficacy in NSCLC by inhibiting macrophage differentiation and M2 macrophage polarization, and combination therapy may be a promising strategy for treating PD-L1 blockade therapy-resistant patients with NSCLC.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research

CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels
CONCLUSIONS: A threshold effect is shown to exist between the peripheral blood CD4 and distant metastasis in NSCLC patients. It was revealed that the risk of distant metastasis is lower when CD4 is maintained between 32 and 44%, whereas low (< 32%) or high (> 44) levels of CD4 are associated with an increased risk of distant metastasis in NSCLC patients.PMID:37733240 | DOI:10.1007/s00432-023-05418-2
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Ying Bai Yafeng Liu Jing Wu Rui Miao Zhi Xu Chunxiao Hu Jiawei Zhou Jianqiang Guo Jun Xie Zilun Shi Xuansheng Ding Yingru Xing Dong Hu Source Type: research

Clinical outcomes of ramucirumab plus docetaxel in the treatment of patients with non-small cell lung cancer after immunotherapy: a systematic literature review
CONCLUSIONS: Cumulatively, these results support the combination of ramucirumab plus docetaxel as an effective and safe subsequent therapy for the treatment of patients with metastatic NSCLC with disease progression irrespective of previous ICI treatment.PMID:37731641 | PMC:PMC10507469 | DOI:10.3389/fonc.2023.1247879
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Edward B Garon Carla Visseren-Grul Maria Teresa Rizzo Tarun Puri Suresh Chenji Martin Reck Source Type: research

Effectiveness and safety of Shenqi Fuzheng injection combined with platinum-based chemotherapy for treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis
CONCLUSION: SFI combined with PBC for the treatment of advanced NSCLC improved the ORR, DCR, and quality of life, and reduced the incidence of myelosuppression and gastrointestinal adverse reactions. However, considering the limitations of existing evidence, further verification using high-quality RCTs is required.SYSTEMATIC REVIEW REGISTRATION: https://inplasy.com/inplasy-2022-7-0026, identifier INPLASY202270026.PMID:37731634 | PMC:PMC10507621 | DOI:10.3389/fonc.2023.1198768
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Chenxi Qiao Shuaihang Hu Dandan Wang Kangdi Cao Zhuo Wang Xinyan Wang Xiumei Ma Zheng Li Wei Hou Source Type: research

CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels
CONCLUSIONS: A threshold effect is shown to exist between the peripheral blood CD4 and distant metastasis in NSCLC patients. It was revealed that the risk of distant metastasis is lower when CD4 is maintained between 32 and 44%, whereas low (< 32%) or high (> 44) levels of CD4 are associated with an increased risk of distant metastasis in NSCLC patients.PMID:37733240 | DOI:10.1007/s00432-023-05418-2
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Ying Bai Yafeng Liu Jing Wu Rui Miao Zhi Xu Chunxiao Hu Jiawei Zhou Jianqiang Guo Jun Xie Zilun Shi Xuansheng Ding Yingru Xing Dong Hu Source Type: research

Pneumonitis in Patients Receiving Thoracic  Radiotherapy and Osimertinib: A Multi-Institutional Study
CONCLUSIONS: Although the overall rate of pneumonitis in patients receiving TRT and osimertinib was relatively low, there was a small risk of severe toxicity. The mean lung dose was associated with an increased risk of developing pneumonitis. These findings inform decision-making for patients and providers.PMID:37732171 | PMC:PMC10507641 | DOI:10.1016/j.jtocrr.2023.100559
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Leou Ismael Banla Alice Tzeng John P Baillieul Melin J Kandekhar Kelly J Fitzgerald Jaclyn LoPiccolo Holly A Poitras Daniel E Soto Julia K Rotow Lisa Singer Henning Willers David E Kozono Pasi A Janne Raymond H Mak Zofia Piotrowska Florence K Keane Benjam Source Type: research

Extremely elevated serum procalcitonin concentration in a patient with stage IV non-small cell lung cancer
Arch Med Sci. 2023 Aug 25;19(5):1581-1583. doi: 10.5114/aoms/170963. eCollection 2023.NO ABSTRACTPMID:37732057 | PMC:PMC10507777 | DOI:10.5114/aoms/170963
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Rafa ł Stando Grzegorz Chmielewski Source Type: research